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Porous silicon as delivery system for po Porous silicon as delivery system for po... - PDF Document (2 M)
Persistent Link 1959.8/103391
Title Porous silicon as delivery system for poorly soluble drugs
Creator(s) Wang, Feng;
Resource Type Thesis
Date 2010
Contributor supervisor Prestidge, Clive
Barnes, Timothy
Rights Copyright 2010 Feng Wang
Dissertation Note Thesis (PhD)--University of South Australia, 2010
Description/Abstract This thesis presents the studies of porous silicon microparticles used as delivery vehicle for improvement of in vitro dissolution and in vivo absorption of poorly water-soluble drugs, i.e. indomethacin and celecoxib. The study outcomes provided significant insight into the factors influencing dissolution kinetics and demonstrated the importance of surface chemistry and pore geometry of porous silicon microparticles to physicochemical properties, dissolution and in vivo absorption performances of these poorly water-soluble drugs.
Subject Porous silicon
physicochemical properties
in vitro dissolution
in vivo absorption
in vitro correlation
in vivo correlation
320501 Pharmaceutical Sciences and Pharmacy
250199 Physical Chemistry not elsewhere classified
291804 Nanotechnology
nano-porous structure
poorly soluble drugs
Language EN-AUS
URA record number unisa46889
Collection ADT
Ian Wark Research Institute
Related collections
Research publications > Research Institutes/Centres/Groups > Ian Wark Research Institute
Theses and Research Proposals > Research Degree Theses